Practice research networks PRNs can support the implementation of evidence based practice in routine services and generate practice based evidence. This paper describes the structure, processes and learning from a new PRN in the Improving Access to Psychological Therapies programme in England, in relation to an implementation framework and using one study as a case example. Challenges related to: ethics and governance processes; communications with multiple stakeholders; competing time pressures and linking outcome data. Enablers included: early tangible outputs and impact; a collaborative approach; engaging with local research leads; clarity of processes; effective dissemination; and committed leadership. Implementation science provides a structure to study the challenges and barriers of translating evidence based practice EBP into routine healthcare in a timely way Proctor et al. Tansella and Thornicroft suggest that the translation of clinical guidelines into routine clinical practice and the reduction of inappropriate variability in practice are important implementation challenges for mental health services.